DFB Pharmaceuticals
Practical innovations for life

Pharmaceutical Development


  • Paclitaxel/Docetaxel
  • The world’s most prescribed chemotherapeutic agents
  • Effective in breast, ovarian, head/neck, gastric, pancreatic, prostatic, non small-cell lung, and other cancers
  • Have antiproliferative and anti-inflammatory activity
  • On the World Health Organization's Model List of Essential Medicines

Currently available drug formulations have significant challenges

  • Intravenous administration yields a number significant systemic side effects
  • Poor aqueous solubility of taxanes requires used of co-solvents which produce their own set of significant side effects
    • Cremophor® for paclitaxel
    • Ethanol/Polysorbate 80 for docetaxel
  • The serious clinical impacts of these side effects prevent the ability to administer optimum effective dosing
  • Blood levels of taxanes fall below clinically effective levels in 4-6 hours – drug administration is recommended every 2-3 weeks